One case of primary pulmonary anaplastic larger cell lymphoma and literature review

Objective To investigate the clinical pathological features, immunohistochemical characteristics, differential diagnosis,treatment and diagnosis of primary pulmonary anaplastic larger cell lymphoma,so as to improve the understanding of this disease. Methods The clinical features,histiocygtic morphology and immunohistochemical characteristics of primary pulmonary anaplastic larger cell lymphoma were retrospectively analysed by studying one case and correlated literatures. Results Clinical features of primary pulmonary anaplastic larger cell lymphoma were mainly cough, sputum, chest pains combined with shortness of breath. The lesions often happened at larger bronchus. The malignant cells were obviously large and multinucleate. Primary pulmonary anaplastic larger cell lymphoma expressed Tcell antigens,CD30( + ) and ALK ( + ). Conclusions Primary pulmonary anaplastic larger cell lymphoma is very rare. Clinical manifestations and radiological images are nonspecific,it is easy to be misdiagnosed.Its diagnosis bases on histopathology and immunohistochemistry. The prognosis of this disease is poor. Key words: Lung ;  Primary ;  Anaplastic ;  Lymphoma