Effects of dl-3-n-butylphthalide on learning-memory ability and Na + -K + -ATPase activity of mitochondria in rats with chronic cerebral hypoperfusion

Objective To explore the effects of dl-3-n-butylphthalide on learning-memory ability and Na+-K+-ATPase activity of mitochondria in rats with chronic cerebral hypoperfusion.Methods Sprague-Dawlay rats were randomly divided into sham group( n= 10) ,model group (Permanent occlusion of bilateral common cawater maze test.Na+-K+-ATPase activity in mitochondria of forebrain tissue were also measured.Results Compared with sham group, memory ability of rats in model group decreased obviously( ( 10.41 ± 3.81 ), ( 25.54 prot- 1 , p ＜0.05 ).The memory ability of rats in large/small dose dl-3-n-butylphthalide groups both increased notably compared with the model group( respectively( 11.72 ± 5.78 ) s and ( 12.48 ± 5.45 ) s, P ＜ 0.01 ) and Na + -0.05 ).The effectives of large dose dl-3-n-butylphthalide and that of small dose dl-3-n-butylphthalide have no significantly differences.Conclusion Dl-3-n-butylphthalide could increase the Na + -K +-ATPase activity and protect mitochondria, improve the learning-memory ability of rats with chronic cerebral hypoperfusion. Key words: dl-3-n-butylphthalide;  Chronic cerebral hypoperfusion;  Learning-memory;  Na+-K+-ATPase