Investigation on the effect and safety of high-intensity focused ultrasound in treating uterine fibroids

Objective To observe the efficacy and safety of high-intensity focused ultrasound （ HIFU ） therapy in uterine fibroids .Methods HIFU was used in the treatment process of 105 patients with uterine fibroids . Then ,we evaluated the treatment effect of HIFU through the follow-up observation of clinical symptoms ,fibroid volume and adverse reaction after treatment for 1 month,3 months,6 months.Results Before treatment,the tumor volume was （48.1 ±17.8）cm3,that was reduced to （30.9 ±10.2）cm3,（24.5 ±8.6）cm3,（18.3 ±7.8）cm3 at 1,3, 6 months after treatment,the differences were statistically significant （t =3.518,5.276,8,119,all P 〈0.01）. 6 months after treatment,the total effective rate was 80.9%.And for patients with muscular uterine fibroids ,uterine fibroids less than 5 cm,the effective rate was up to 91.9% and 93.8%,respectively.Conclusion HIFU has a positive impact on uterine fibroids ,especially for myometrium and smaller fibroids . Key words: High-intensity focused ultrasound ablation; Myometrium; Leiomyoma