Expression of Survivin and P27kip1 in hepatocellular carcinoma and its clinical significance

Objective To investigate the role of Survivin and P27kip1 expression in the pathogenesis of hepatocellular carcinoma(HCC).Methods Forty histologically verified HCC specimens and their neighboring noncancerous tissues were obtained.Immunohistochemistry was used to detect protein expressions of Survivin and P27kip1.Results Survivin protein expression was positive in 34 of 40 (85%)cases.By comparison,no positive expression of Survivin was detected in corresponding tissues.The positive rate of Survivin protein expression in the cases of intrahepatic metastasis was higher than those without intrahepatic metastasis(P<0.05),and the rate of Survivin expression in the cases of portal vein invasion was higher than those without portal vein invasion(P<0.05).The expression of P27kip1 was positive in 8 of 40 (20%) cases and 80% in noncancerous tissues.The expression of P27kip1 was 11.7% in the cases of Survivin expression,which was lower than the cases without Survivin expression(66.7%).Conclusions The optional expression of Survivin have a close correlation with the tumor macastasis and vascular infiltration. Survivin expression may play an important part in HCC,which offer a wide prospective for clinical application in the primitive prognosis of hepatic-carcinoma. Key words: Hepatocellular carcinoma ;  Survivin ;  P27kip1 ;