Clinicopathologic analysis of ten patients with gonadal diffuse large B-cell lymphoma

Objective To investigate the clinicopathologic characteristics, immunophenotype, differential diagnosis, and prognostic factors of gonadal diffuse large B-cell lymphoma (DLBCL). Methods The clinicopathologic data of 10 patients with gonadal DLBCL including morphology and immunohistochemistry were analyzed retrospectively, then the literature was reviewed. Results Among 10 patients, 9 cases were testicular DLBCL, and the median age was 67 years old (40-85 years old); 1 case was ovary DLBCL, and the age was 46 years old. Tumor cells were large to medium-sized under the optical microscope, which were characterized as diffuse infiltration around the duct and the remaining convoluted tubule of testis neoplasms. Most DLBCL (70%, 7/10) immunophenotype analysis showed non-germinal center B-cell (non-GCB) type. Patients were followed up from 6 to 103 months, and 2 patients lost follow-up. The survival number of patients in 1-year, 3-year, and 5-year was 4, 2, 2 respectively. Conclusions Primary gonadal DLBCL is an uncommon extranodal lymphoma, which mainly belongs to non-GCB type with poor prognosis. Comprehensive treatments usually take operation and chemotherapy, and the prognosis should be evaluated by multiple factors. Key words: Lymphoma, large B-cell, diffuse; Neoplasms, gonadal tissue; Testis; Ovary; Clinical characteristic; Pathological subtype; Prognosis