FAP and MMP-1 expression and relationship between them in mice pulmonary fibrosis

Objective To investigate the expression of fibroblast activation protein (FAP) in mice pulmonary fibrosis and the relationship between FAP and MMP-1.Methods The expressions of FAP,α-SMA and MMP-1 were detected with immunohistochemical and Western blot technique in mice pulmonary fibrosis model.Results ① After BLM-A5 induced,the expression of FAP,MMP-1 and α-SMA were strongly correlated with the stage of lung fibrosis.The expression of FAP was positively correlated with MMP-1.② The expression of FAP was correlated with the lung fibrosis,but weakly positive in control group with Western-bolt analysis.The expression of MMP-1,α-SMA was also correlated with the lung fibrosis degree.Conclusions FAP was strongly correlated with the alveolitis and the lung fibrosis degree.FAP and MMP 1 might play a synergistic role in the ECM remodeling of pulmonary fibrosis. Key words: Fibroblast activation protein;  Lung fibrosis ;  Fibroblast ;  Matrixmetalloproteinases-1 ;  Mouse