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2016•International journal of pediatricsRequires access

Biomarkers of preterm infant low birth weight brain damage

Juan Tang, Chen Shan

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Abstract

Along with contemporary development of life support technology in perinatology and neonatal intensive care, mortality of preterm infants has been reduced.However, the problems caused by the brain damage have been attracting more and more attention.The long-term outcome of prematures depends on their nervous system sequelae among the total complications.Preterm infants′ brain damage mainly includes intraventricular hemorrhage(IVH)and periventricular leukomalacia(PVL). IVH and its complications are the main causes of early death, mental and physical developmental disorder of neonatals.Thus, the early diagnosis of brain damage, especially PVL, has become a serious problem that we are going to face.The scholars in or aboard hao payed close attention to these markers, such as MBP、S100B、ACT A、NF-L、NGB、MMP、IL-6、IL-10、IL-11、NSE.The paper reviews these biological markers. Key words: Brain damage; Markers; Biology; Preterm infant; Low birth weight

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Along with contemporary development of life support technology in perinatology and neonatal intensive care, mortality of preterm infants has been reduced.However, the problems caused by the brain damage have been attracting more and more attention.The long-term outcome of prematures depends on their nervous system sequelae among the total complications.Preterm infants′ brain damage mainly includes intraventricular hemorrhage(IVH)and periventricular leukomalacia(PVL). IVH and its complications are the main causes of early death, mental and physical developmental disorder of neonatals.Thus, the early diagnosis of brain damage, especially PVL, has become a serious problem that we are going to face.The scholars in or aboard hao payed close attention to these markers, such as MBP、S100B、ACT A、NF-L、NGB、MMP、IL-6、IL-10、IL-11、NSE.The paper reviews these biological markers. Key words: Brain damage; Markers; Biology; Preterm infant; Low birth weight

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Available abstract

Along with contemporary development of life support technology in perinatology and neonatal intensive care, mortality of preterm infants has been reduced.However, the problems caused by the brain damage have been attracting more and more attention.The long-term outcome of prematures depends on their nervous system sequelae among the total complications.Preterm infants′ brain damage mainly includes intraventricular hemorrhage(IVH)and periventricular leukomalacia(PVL). IVH and its complications are the main causes of early death, mental and physical developmental disorder of neonatals.Thus, the early diagnosis of brain damage, especially PVL, has become a serious problem that we are going to face.The scholars in or aboard hao payed close attention to these markers, such as MBP、S100B、ACT A、NF-L、NGB、MMP、IL-6、IL-10、IL-11、NSE.The paper reviews these biological markers. Key words: Brain damage; Markers; Biology; Preterm infant; Low birth weight

Key concepts: Medicine, Periventricular leukomalacia, Brain damage, Low birth weight, Intraventricular hemorrhage, Pediatrics, Intensive care medicine, Gestational age

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