2017•Zhongguo jiceng yiyaoRequires access
The correlation between thyroid function and arteriosclerosis in elderly population
Meiju Wang, Yunjie Wang
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Abstract
Objective
To learn the correlation between thyroid function and arteriosclerosis in elderly population, and to provide research data for early clinical intervention.
Methods
71 elderly patients with hypothyroidism were selected as A group, 76 elderly patients with subclinical hypothyroidism were selected as B group, 70 healthy elderly cases were selected as C group.Triiodothyronine (FT3), tetraiodothyronine (FT4), thyrotrophin (TSH), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), C reactive protein (CRP) levels of the three groups were detected.Carotid artery intima media thickness (CIMT) was examined by color Doppler ultrasonography.
Results
FT4 levels of A group, B group were (5.25±4.17)pmol/L, (10.74±5.02)pmol/L respectively, which were lower than (18.53±6.38)pmol/L of C group.TSH levels of A group, B group were (16.45±6.96)mU/L, (6.25±3.84)mU/L respectively, which were higher than (3.37±1.13)mU/L of C group (t=14.650, 8.232, 15.522, 6.037, all P<0.05). FT4 level of A group was lower than that of B group, TSH level of A group was higher than B group (t=7.185, 11.097, P<0.05). TC, LDL-C levels of A group, B group were (5.96±1.01)mmol/L, (4.15±1.69)mmol/L, (5.64±0.94)mmol/L, (3.64±1.17)mmol/L respectively, which were higher than those of C group [(5.17±1.12)mmol/L, (3.20±1.06)mmol/L](t=4.400, 2.754, 3.992, 2.374, all P<0.05). TC, LDL-C levels of A group were higher than B group (t=1.990, 2.139, all P<0.05). CIMT, CRP levels of A group, B group were (0.90±0.23)mm, (6.20±1.31)mg/L, (0.79±0.17)mm, (4.55±1.05)mg/L respectively, which were higher than those of C group [(0.68±0.11)mm, (3.12±0.88)mg/L] (t=7.229, 4.599, 16.364, 8.878, all P<0.05). CIMT, CRP levels of A group were higher than B group (t=3.312, 8.453, all P<0.05). CIMT and TSH, LDL-C, CRP levels were positively correlated (r=0.789, 0.647, 0.583, all P<0.05), CIMT and FT4 levels were negatively correlated (r=-0.636, P<0.05).
Conclusion
Hypothyroidism, subclinical hypothyroidism are associated with atherosclerosis in elderly population, and elderly patients with hypothyroidism, subclinical hypothyroidism are at high risk of atherosclerosis.
Key words:
Atherosclerosis; Hypothyroidism; Aged