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2019•Zhonghua laonian yixue zazhiRequires access

Research progress on lamin and Hutchinson-Gilford progeria syndrome

Tianwei Xia, Fang Wang, Guowei Zhou, Chao Zhang, Qing Yan Jiang, Jirong Shen

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Abstract

Many studies have shown that abnormal expression and modification of lamin are closely related to aging.Hutchinson-Gilford progeria syndrome(HGPS)is a rare and severe premature aging disease caused by mutations in the gene encoding nuclear envelope proteins of A-type lamins(LMNA). The pathogenesis of HGPS is similar to the aging process of normal individuals, thus research on HGPS will be helpful for understanding the mechanisms of senescence and developing anti-aging drugs.This paper reviews recent advances in lamin and the pathogenesis and treatment of HGPS, in order to provide a reference for further basic and clinical research on HGPS. Key words: Aging; Lamin; Hutchinson-Gilford progeria syndrome

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What this paper is about

Many studies have shown that abnormal expression and modification of lamin are closely related to aging.Hutchinson-Gilford progeria syndrome(HGPS)is a rare and severe premature aging disease caused by mutations in the gene encoding nuclear envelope proteins of A-type lamins(LMNA). The pathogenesis of HGPS is similar to the aging process of normal individuals, thus research on HGPS will be helpful for understanding the mechanisms of senescence and developing anti-aging drugs.This paper reviews recent advances in lamin and the pathogenesis and treatment of HGPS, in order to provide a reference for further basic and clinical research on HGPS. Key words: Aging; Lamin; Hutchinson-Gilford progeria syndrome

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Available abstract

Many studies have shown that abnormal expression and modification of lamin are closely related to aging.Hutchinson-Gilford progeria syndrome(HGPS)is a rare and severe premature aging disease caused by mutations in the gene encoding nuclear envelope proteins of A-type lamins(LMNA). The pathogenesis of HGPS is similar to the aging process of normal individuals, thus research on HGPS will be helpful for understanding the mechanisms of senescence and developing anti-aging drugs.This paper reviews recent advances in lamin and the pathogenesis and treatment of HGPS, in order to provide a reference for further basic and clinical research on HGPS. Key words: Aging; Lamin; Hutchinson-Gilford progeria syndrome

Key concepts: Progeria, LMNA, Lamin, Premature aging, Pathogenesis, Biology, Disease, Senescence

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