2003•Unpublished venueRequires access

Expression of Survivin in pancreatic carcinoma and its relation to VEGF

刘江伟, 李开宗, 窦科峰

Abstract

目的探讨凋亡抑制蛋白Survivin在胰腺癌组织中的表达和血管内皮生长因子(VEGF)表达的关系.方法用免疫组织化学Envision法对51例胰腺导管癌Survivin和VEGF的表达进行检测.结果 51例胰腺导管癌中Survivin蛋白的表达率为80.4%,VEGF的表达率为68.6%; 二者在11例癌旁非肿瘤胰腺组织中均未发现阳性表达.Survivin的表达与组织学分级有关(P 0.05); VEGF的表达与临床分期、淋巴结转移有关(P 0.05); Survivin的表达与VEGF的表达密切相关(P<0.01).二者的表达与病人的性别、年龄、肿瘤的大小、部位均无关.结论 Survivin和VEGF可能在胰腺癌的发生发展过程中起关键作用,二者在血管生成过程中密切相关,可能为胰腺癌的治疗提供了新的靶点.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: VEGF receptors, Pancreatic carcinoma, Survivin, Carcinoma, Expression (computer science), Relation (database), Cancer research, Pancreatic cancer