Ischemic postconditioning and mitochondrial permeability transition pore

Background Ischemic postconditioning alleviating ischemia reperfusion injury had been confirmed by experimental study and clinical study.The mechanism involves enhancement of organ antioxidant capacity and inhibition of apoptosis.However,in recent years,it has been put forward that mitochondrial permeability transition pore plays an important role in ischemic postconditioning alleviating ischemia reperfusion injury.This review will discuss the mechanisms of mitochondrial permeability transition pore in ischemic postconditioning.Objective It elaborates the role of mitochondrial permeability transition pore (MPTP) in the mechanism of IPo organ protection.Content MPTP is identified as the final target of ischemic postconditioning.It is a composite protein channel located inside the mitochondrial outer membrane.Opening of MPTP is favored by intracellular calcium overload,reduced mitochondrial membrane potential,increased reactive oxygen species,release of proapoptotic proteins.IPo attenuates reperfusion injury through several signal transduction pathways,and regulation of mitochondrial permeability transition pore is an important aspect.Trend The MPTP research contributes to the exploration of the IPo organ protection mechanisms. Key words: Ischemic postconditioning; Mitochondrial permeability transition pore; Mitochondrial KATP channel