ScholarLens Back to search
2017•Chin J Postgrad MedRequires access

The significance of serum procalcitonin and C-reactive protein in the diagnosis of spontaneous bacterial peritonitis in patients with liver cirrhosis combined with ascites

Yunqi Hua, Cuiyun Zhao, Min Li, Yunjian Jin, Yi Zhao

Open publisher page 2 citations

Abstract

Objective To determine the role of serum procalcitonin (PCT) and C-reactive protein (CRP) in predicting spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis combined with ascites. Methods Ninety-eight patients with liver cirrhosis combined with ascites were enrolled, including 48 cases with SBP (SBP group) and 50 cases without SBP (non-SBP group). The levels of serum PCT and CRP were compared between 2 groups. The receiver operating characteristic (ROC) curves were used to evaluate the diagnostic SBP value of PCT and CRP levels in patients with liver cirrhosis combined with ascites. Results The serum PCT and CRP levels in SBP group were significantly higher than those in non-SBP group: 3.90 (6.95) μg/L vs. 0.50 (0.43) μg/L and 20.80 (11.27) mg/L vs. 10.87 (6.22) mg/L, and there were statistical differences (P<0.01). The ROC cures results showed that the areas under the curve of serum PCT and CRP levels were 0.924 (95% CI 0.860-0.987) and 0.852 (95% CI 0.777- 0.926), and the optimal cut-off of predicting SBP in patients with liver cirrhosis combined with ascites were 0.81 μg/L and 13.89 mg/L. The sensitivity was 91.7% and 85.4%, and the specificity was 80.0% and 70.0% respectively. The mortality in SBP group was significant higher than that in non-SBP group: 20.83% (10/48) vs. 6.00% (3/50), and there was statistical difference (P<0.05). In SBP group, the serum PCT and CRP levels in death patients were significant higher than those in survival patients: 13.00 (10.90) μg/L vs. 2.50 (5.30) μg/L and 35.40 (31.22) mg/L vs. 18.05(10.15) mg/L, and there were statistical differences (P<0.01 or < 0.05). Conclusions The increase of serum PCT and CRP levels can be used as an important diagnostic index for SBP in patients with liver cirrhosis combined with ascites, and has predictive value for prognosis. Key words: Peritonitis; Liver cirrhosis; C-reactive protein; Procalcitonin

About this research paper

What this paper is about

Objective To determine the role of serum procalcitonin (PCT) and C-reactive protein (CRP) in predicting spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis combined with ascites. Methods Ninety-eight patients with liver cirrhosis combined with ascites were enrolled, including 48 cases with SBP (SBP group) and 50 cases without SBP (non-SBP group). The levels of serum PCT and CRP were compared between 2 groups. The receiver operating characteristic (ROC) curves were used to evaluate the diagnostic SBP value of PCT and CRP levels in patients with liver cirrhosis combined with ascites. Results The serum PCT and CRP levels in SBP group were significantly higher than those in non-SBP group: 3.90 (6.95) μg/L vs. 0.50 (0.43) μg/L and 20.80 (11.27) mg/L vs. 10.87 (6.22) mg/L, and there were statistical differences (P<0.01). The ROC cures results showed that the areas under the curve of serum PCT and CRP levels were 0.924 (95% CI 0.860-0.987) and 0.852 (95% CI 0.777- 0.926), and the optimal cut-off of predicting SBP in patients with liver cirrhosis combined with ascites were 0.81 μg/L and 13.89 mg/L. The sensitivity was 91.7% and 85.4%, and the specificity was 80.0% and 70.0% respectively. The mortality in SBP group was significant higher than that in non-SBP group: 20.83% (10/48) vs. 6.00% (3/50), and there was statistical difference (P<0.05). In SBP group, the serum PCT and CRP levels in death patients were significant higher than those in survival patients: 13.00 (10.90) μg/L vs. 2.50 (5.30) μg/L and 35.40 (31.22) mg/L vs. 18.05(10.15) mg/L, and there were statistical differences (P<0.01 or < 0.05). Conclusions The increase of serum PCT and CRP levels can be used as an important diagnostic index for SBP in patients with liver cirrhosis combined with ascites, and has predictive value for prognosis. Key words: Peritonitis; Liver cirrhosis; C-reactive protein; Procalcitonin

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To determine the role of serum procalcitonin (PCT) and C-reactive protein (CRP) in predicting spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis combined with ascites. Methods Ninety-eight patients with liver cirrhosis combined with ascites were enrolled, including 48 cases with SBP (SBP group) and 50 cases without SBP (non-SBP group). The levels of serum PCT and CRP were compared between 2 groups. The receiver operating characteristic (ROC) curves were used to evaluate the diagnostic SBP value of PCT and CRP levels in patients with liver cirrhosis combined with ascites. Results The serum PCT and CRP levels in SBP group were significantly higher than those in non-SBP group: 3.90 (6.95) μg/L vs. 0.50 (0.43) μg/L and 20.80 (11.27) mg/L vs. 10.87 (6.22) mg/L, and there were statistical differences (P<0.01). The ROC cures results showed that the areas under the curve of serum PCT and CRP levels were 0.924 (95% CI 0.860-0.987) and 0.852 (95% CI 0.777- 0.926), and the optimal cut-off of predicting SBP in patients with liver cirrhosis combined with ascites were 0.81 μg/L and 13.89 mg/L. The sensitivity was 91.7% and 85.4%, and the specificity was 80.0% and 70.0% respectively. The mortality in SBP group was significant higher than that in non-SBP group: 20.83% (10/48) vs. 6.00% (3/50), and there was statistical difference (P<0.05). In SBP group, the serum PCT and CRP levels in death patients were significant higher than those in survival patients: 13.00 (10.90) μg/L vs. 2.50 (5.30) μg/L and 35.40 (31.22) mg/L vs. 18.05(10.15) mg/L, and there were statistical differences (P<0.01 or < 0.05). Conclusions The increase of serum PCT and CRP levels can be used as an important diagnostic index for SBP in patients with liver cirrhosis combined with ascites, and has predictive value for prognosis. Key words: Peritonitis; Liver cirrhosis; C-reactive protein; Procalcitonin

Key concepts: Procalcitonin, Spontaneous bacterial peritonitis, Ascites, Cirrhosis, Gastroenterology, Medicine, Internal medicine, Receiver operating characteristic

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The significance of serum procalcitonin and C-reactive protein in the diagnosis of spontaneous bacterial peritonitis in patients with liver cirrhosis combined with ascites — Research Paper | ScholarLens