Effects of inhalation of sevoflurane at different time on pulmonary function and oxidative stress in patients with one lung ventilation

Objective To investigate effects of inhalation of sevoflurane at different time on pulmonary function and oxidative stress in patients with one lung ventilation. Methods 80 patients who needed external surgery according to the random grouping principle, were divided into sevoflurane preconditioning group(OLV for 30min after inhalation of sevoflurane), sevoflurane treatment group(OLV inhalation of sevoflurane), sevoflurane inhalation group(inhalation of sevoflurane), total intravenous group(propofol and remifentanil anesthesia) four groups, 20 patients in each group, each group was treated accordingly. The differences of serum malondialdehyde(MDA), superoxide dismutase(SOD), lactate dehydrogenase(LDH) and intrapulmonary shunt(Qs/Qt) in the four groups were observed and compared at different time points. Results Compared with the other three groups, the intrapulmonary shunt fraction of the sevoflurane preconditioning group were significantly lower[(4.9±0.6)% vs. (6.1±0.5)%, (6.3±0.6)%, (5.9±0.4)%](χ2=5.415, 5, 882, 4.977, all P<0.05). The serum levels of MDA, SOD, LDH in the sevoflurane pretreatment group were significantly lower than those in the other three groups[(5.06±2.10)nmol/mL vs. (13.04±3.27)nmol/mL, (12.40±4.28)nmol/mL, (13.13±2.30)nmol/ml], [(58.7±5.9)U/L vs. (84.9±13.8)U/L, (93.9±21.1)U/L, (84.2±11.2)U/L], [(16.3±2.1)U/L vs. (43.1±7.2)U/L, (45.4±6.7)U/L, (35.8±5.1)U/L](t=8.076, 7.448, 8.277; 12.917, 15.506, 12.586; 11.375, 12.239, 8.220, all P<0.05). Conclusion Thoracic surgery in patients with one lung ventilation during anesthesia, using sevoflurane preconditioning anesthesia surgery can effectively improve the patients with intrapulmonary shunt rate, reduce the level of oxidative stress and improve the prognosis, it is worthy of further clinical application. Key words: Sevoflurane; Pulmonary ventilation; Anesthesia, caudal; Oxidative stress