Effects of low nitrogen and low calorie parenteral nutrition combined with enteral nutrition on inflammatory factors and immune function in patients with gastric cancer

Objective To investigate the effect of low nitrogen and low calorie parenteral nutrition combined with enteral nutrition support on inflammatory factors and immune function in patients with gastric cancer. Methods From May 2013 to May 2015, ninety patients with gastric cancer underwent surgical treatment in the Affiliated Hospital of Yanbian University were selected in the research, and they were divided into control group and observation group according to different methods of nutritional support, with 45 cases in each group.The control group received total parenteral nutrition support, the observation group was given low nitrogen and low calorie parenteral nutrition and enteral nutrition support, and supplemented by targeted nursing measures.The changes of levels of inflammatory factors and immune proteins in the two groups before operation and 7d after operation were compared.All patients were followed up for 6 months, and the quality of life and nursing satisfaction rate were compared between the two groups. Results At 7d after operation, the levels of immunoglobulin IgA, IgM and IgG in the observation group were (2.62±0.43)g/L, (1.93±0.52)g/L, (14.58±3.32)g/L, respectively, which were significantly higher than those before operation [(2.01±0.30)g/L, (1.22±0.40)g/L, (12.42±5.64)g/L, t=7.805, 7.260, 2.214, all P<0.05] and those of the control group [(2.12±0.52)g/L, (1.53±0.41)g/L, (12.86±4.34)g/L, t=4.971, 4.052, 2.112, all P<0.05]. At 7d after operation, the levels of C reactive protein(CRP), tumor necrosis factor-α(TNF-α) in the observation group were (108.52±17.53)mg/L, (135.63±28.51)ng/L, respectively, which were lower than those before operation [(142.35±15.82)mg/L, (156.65±25.54)ng/L, t=9.611, 3.684, all P<0.05] and those of the control group[(135.68±14.54)mg/L, (145.52±27.53)ng/L, t=8.000, 3.824, all P<0.05], the level of interleukin-2(IL-2) was higher than those before operation[(65.71±10.23)ng/L vs.(54.32±7.83)ng/L, t=5.931, P<0.05] and that of control group[(57.62±5.86)ng/L, t=4.603, P<0.05]. At 6 months after operation, the quality of life scores of the observation group were higher than those of the control group(t=7.444, 6.892, 4.884, 5.957, 7.784, 12.992, 3.851, 6.706, all P<0.05). The nursing satisfaction rate of the observation group was 97.78%, which was higher than 82.22% of the control group (χ2=6.049, P<0.05). Conclusion Low nitrogen and low calorie parenteral nutrition combined with enteral nutrition support can effectively improve the immune function of patients with gastric cancer, reduce the inflammatory response and ensure the quality of life of the prognosis, which is suitable for clinical application. Key words: Parenteral nutrition; Enteral nutrition; Stomach neoplasms; Inflammation mediators; Immunologic