2011•Zhonghua neifenmi daixie zazhiRequires access

Relationship between liver X receptor (LXR) expression and hepatic glucose metabolism in the insulin resistant obese rats

Ying Dong, Wei Liu

Abstract

Twenty-seven male SD rats were assigned to 3 groups: control, obese, and obese with diabetes groups. Serum corticosterone was determined and euglycemic-hyperinsulinemic clamp was carried out. Expressions of liver X receptor ( LXR), 11 β-hydroxysteroid dehydrogenase 1 ( 11 β-HSD1 ), and glucocorticoid receptor (GR) were determined by real-time PCR. Both groups of obese rats were insulin-resistant, with up-regulated LXR mRNA and down-regulated 11 β-HSD1 mRNA( both P＜0.05 ). Key words: Liver X receptor; 11 β-hydroxysteriod dehydrogenase 1; Obesity; Insulin resistance

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Key concepts: Internal medicine, Endocrinology, Insulin resistance, Liver X receptor, Glucocorticoid receptor, Obesity, Glucocorticoid, Receptor