Study on the relationship between urinary albumin and serum bilirubin in patients with type 2 diabetes mellitus

Objecttve To explore the relationship between urine albumin and serum bilirubin in patients with type 2 diabetes mellitus.Methods A total of 435 patients with type 2 diabetes mellitus from June 2011 to May 2012 were divided into 3 groups according to 24 hours urinary albumin excretion rate (UAER):normal albuminuria group (UAER ≤ 20 μg/min) in 217 cases; microalbuminuria group (UAER 21-199 μg/min,early diabetic nephropathy group) in 107 cases; great albuminuria group (UAER ≥200 μ g/min,clinical diabetic nephropathy group) in 111 cases.The difference of serum bilirubin level was compared among 3 groups.The risk factors were analyzed by multiple factors unconditional Logistic stepwise regression analysis.Results The serum total bilirubin,direct bilirubin and indirect bilirubin was (9.55 ± 3.48),(2.44 ± 1.03) and (7.11 ± 3.51) μ mol/L in clinical diabetic nephropathy group,which was lower than that in early diabetic nephropathy group[(10.92 ± 3.70),(2.71 ± 1.15),(8.23 ± 3.71) μ mol/L]and normal albuminuria group [(14.67 ±4.59),(2.86 ± 1.34),(11.84 ±4.48)μmol/L],and there was significant difference (P ＜0.05).Unconditional Logistic stepwise regression analysis showed that the correlation existed between glycosylated hemoglobin,blood uric acid,high density lipoprotein cholesferol and total bilirubin and diabetic nephropathy.Serum total bilirubin,high density lipoprotein cholesferol was protective factor,glycosylated hemoglobin,blood uric acid was risk factor.Conclusion High serum bilirubin level is conducive to fight oxidative stress,reduce inflammation,prevent lipid peroxidation,and suppress or delay the occurrence and development of diabetic nephropathy. Key words: Diabetic nephropathies;  Oxidative stress;  Albuminuria;  Bilirubin