2016•Zhonghua shiyong erke linchuang zazhiRequires access
Effects of live combined bifidobacterium, lactobacillus and enterococcus powder on IgE and interleukin-17 levels in atopic children with bronchiolitis
Guochang Xue, Mingxing Ren, Shen Linna, Huan Xia, Yuejuan Song
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Abstract
Objective
To observe the effects of live combined bifidobacterium, lactobacillus and enterococcus powder on immunoglobulin E (IgE) and interleukin-17 (IL-17) in atopic children with bronchiolitis.
Methods
Sixty cases of atopic children with bronchiolitis were randomly divided into the therapy group (30 cases) and the control group (30 cases). Twenty-five healthy children were enrolled as the healthy control group.Both the therapy group and the control group were given traditional therapy.The therapy group received live combined bifidobacterium, lactobacillus and enterococcus powder for 2 months.The change of IgE and IL-17 levels were observed during the acute stage, remission stage and after receiving live combined bifidobacterium, lactobacillus and enterococcus powder for 2 months.
Results
(1) The levels of IgE and IL-17 of therapy group[(132.36±9.50) μg/L and (77.76±7.95) μg/L] during acute stage were markedly higher than those in the healthy control group [(52.80±4.92) μg/L and (46.92±4.79) μg/L](all P<0.001). The levels of IgE and IL-17 of control group [(128.83±8.06) μg/L and (76.61±6.18) μg/L]during remission stage were markedly higher than those in the healthy control group [(52.80±4.92) μg/L and (46.92±4.79) μg/L](all P<0.001). (2) The levels of IgE of therapy group (56.67±9.20) μg/L after receiving live combined bifidobacterium, lactobacillus and enterococcus powder for 2 months were markedly lower than those in the control group (70.50±11.38) μg/L (P<0.001). The levels of IL-17 of therapy group [(49.63±6.35) μg/L] at the time after receiving live combined bifidobacterium, lactobacillus and enterococcus powder for 2 months were markedly lower than these in the control group (54.77±6.33) μg/L (P=0.003).
Conclusion
Receiving live combined bifidobacterium, lactobacillus and enterococcus powder for two months can decrease the IgE and IL-17 levels in atopic children with bronchiolitis.
Key words:
Bronchiolitis; Live combined bifidobacterium, lactobacillus and enterococcus powder; Immunoglo-bulin E; Interleukin-17