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2014•Intern J Endocrinol MetabRequires access

Effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy

Huizhu Ren, Juhong Yang, Miaoyan Zheng, Ying Wang, Yan Kong, Hang Guo, Chunyan Shan

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Abstract

Objective To investigate the effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy.Methods Fifty patients with early diabetic nephropathy were randomly divided into treatment group (n=25) and control group (n=25).Both groups adopted the diabetic diet,exercise programs.Patients in the treatment group were treated with Shenyankangfu tablet on the base of their blood glucose and lipids control,while patients in the control group received placebo.The changes of serum creatinine (Scr),blood urea nitrogen (BUN),glycated hemoglobulinA 1 c (HbA 1 c),hs-C reactive protein (CRP),and 24-hour urine total protein,albumin,N-acetyl-β-amino-glucosidase (NAG),β2-microglobulin (β2-MG),retinol binding protein (RBP) before and after the treatment were tested.Results The bloodhs-CRP,urinary NAG dropped,β2-MG,RBP decreased significantly in treatment group (all P＜0.05),but did not change in control group (all P ＞0.05).The level of blood hs-CRP decreased from (4.52 ± 2.01) mg/L to (3.09 ± 0.85) mg/L,urinary NAG dropped from (19.28 ± 7.04) U/L to (13.70 ± 6.61) U/L,β2-MG reduced from (0.56 ± 0.13)mg/L to (0.35 ± 0.20) mg/L,RBP decreased from (2.83 ± 1.21) mg/L to (1.40 ± 0.69) mg/L respectively (t value were 2.808,4.523,3.418 and 3.977,all P ＜0.05) in treatment group.After treatment,24-hour urinary total protein and albumin decreased in both groups (all P＜0.05),but reduced more in treatment group (P＜0.05).The level of 24-hour urinary total protein decreased from (0.40 ± 0.12) g/24 h to(0.28 ± 0.15) g/24 h,and urinary albumin decreased from (105.91 ± 41.50) mg/24 h to (65.05 ± 42.52) mg/24 h,respectively (t value were 5.726,4.234,all P＜0.05) in treatment group.Conclusion Shenyankangfu tablet can reduce glomerular urinary protein excretion and tubular injury. Key words: Shenyankangfu tablet;  Early diabetic nephropathy;  Glomerular;  Tubular;  Iconic protein/enzyme

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Objective To investigate the effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy.Methods Fifty patients with early diabetic nephropathy were randomly divided into treatment group (n=25) and control group (n=25).Both groups adopted the diabetic diet,exercise programs.Patients in the treatment group were treated with Shenyankangfu tablet on the base of their blood glucose and lipids control,while patients in the control group received placebo.The changes of serum creatinine (Scr),blood urea nitrogen (BUN),glycated hemoglobulinA 1 c (HbA 1 c),hs-C reactive protein (CRP),and 24-hour urine total protein,albumin,N-acetyl-β-amino-glucosidase (NAG),β2-microglobulin (β2-MG),retinol binding protein (RBP) before and after the treatment were tested.Results The bloodhs-CRP,urinary NAG dropped,β2-MG,RBP decreased significantly in treatment group (all P＜0.05),but did not change in control group (all P ＞0.05).The level of blood hs-CRP decreased from (4.52 ± 2.01) mg/L to (3.09 ± 0.85) mg/L,urinary NAG dropped from (19.28 ± 7.04) U/L to (13.70 ± 6.61) U/L,β2-MG reduced from (0.56 ± 0.13)mg/L to (0.35 ± 0.20) mg/L,RBP decreased from (2.83 ± 1.21) mg/L to (1.40 ± 0.69) mg/L respectively (t value were 2.808,4.523,3.418 and 3.977,all P ＜0.05) in treatment group.After treatment,24-hour urinary total protein and albumin decreased in both groups (all P＜0.05),but reduced more in treatment group (P＜0.05).The level of 24-hour urinary total protein decreased from (0.40 ± 0.12) g/24 h to(0.28 ± 0.15) g/24 h,and urinary albumin decreased from (105.91 ± 41.50) mg/24 h to (65.05 ± 42.52) mg/24 h,respectively (t value were 5.726,4.234,all P＜0.05) in treatment group.Conclusion Shenyankangfu tablet can reduce glomerular urinary protein excretion and tubular injury. Key words: Shenyankangfu tablet;  Early diabetic nephropathy;  Glomerular;  Tubular;  Iconic protein/enzyme

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Available abstract

Objective To investigate the effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy.Methods Fifty patients with early diabetic nephropathy were randomly divided into treatment group (n=25) and control group (n=25).Both groups adopted the diabetic diet,exercise programs.Patients in the treatment group were treated with Shenyankangfu tablet on the base of their blood glucose and lipids control,while patients in the control group received placebo.The changes of serum creatinine (Scr),blood urea nitrogen (BUN),glycated hemoglobulinA 1 c (HbA 1 c),hs-C reactive protein (CRP),and 24-hour urine total protein,albumin,N-acetyl-β-amino-glucosidase (NAG),β2-microglobulin (β2-MG),retinol binding protein (RBP) before and after the treatment were tested.Results The bloodhs-CRP,urinary NAG dropped,β2-MG,RBP decreased significantly in treatment group (all P＜0.05),but did not change in control group (all P ＞0.05).The level of blood hs-CRP decreased from (4.52 ± 2.01) mg/L to (3.09 ± 0.85) mg/L,urinary NAG dropped from (19.28 ± 7.04) U/L to (13.70 ± 6.61) U/L,β2-MG reduced from (0.56 ± 0.13)mg/L to (0.35 ± 0.20) mg/L,RBP decreased from (2.83 ± 1.21) mg/L to (1.40 ± 0.69) mg/L respectively (t value were 2.808,4.523,3.418 and 3.977,all P ＜0.05) in treatment group.After treatment,24-hour urinary total protein and albumin decreased in both groups (all P＜0.05),but reduced more in treatment group (P＜0.05).The level of 24-hour urinary total protein decreased from (0.40 ± 0.12) g/24 h to(0.28 ± 0.15) g/24 h,and urinary albumin decreased from (105.91 ± 41.50) mg/24 h to (65.05 ± 42.52) mg/24 h,respectively (t value were 5.726,4.234,all P＜0.05) in treatment group.Conclusion Shenyankangfu tablet can reduce glomerular urinary protein excretion and tubular injury. Key words: Shenyankangfu tablet;  Early diabetic nephropathy;  Glomerular;  Tubular;  Iconic protein/enzyme

Key concepts: Internal medicine, Blood urea nitrogen, Diabetic nephropathy, Endocrinology, Creatinine, Retinol binding protein, Nephropathy, Medicine

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