Relationship between the clinical manifestations and the changes of atypical lymphocyte and lymphocyte subsets in children with infectious mononucleosis

Objective To investigate atypical lymphocyte and lymphocyte subsets in children with infectious mononucleosis(IM)and its relationship with the clinical symptoms by retrospective method. Methods Two hundred and six children were diagnosed as infectious mononucleosis. Atypical types, lymphocyte subsets, and clinical symptoms and their relationship were evaluated and analyzed. Results In the IM children increased, decreased, increased and NK cells decreased. The control group was(64.23±6.26)%,(32.96±8.68)%,(20.25±7.45)%,(14.68±5.4)%,the IM group was(84.13±14.64)%,(18.45±5.14)%,(54.46±16.82)%,(4.65±1.50)%, the difference was statistically significant(P<0.001).92.9%patients had more 10%atypical lymphocytes. The children with more than 20%atypical lymphocytes had higher v8 and NK cells decreased,(58.78±16.67)%, (3.28±1.57)%. The difference with the atypical cells more than 10%less than 20%and the group less than 10%has statistically sighnificant which were(54.53±15.12)%,(4.55±1.64)%,(50.25±14.23)%,(5.13±1.84)%(P<0.001). The serious type of IM children had higher ratio of increased and decreased NK cells and had statistically significant compared with the light group, which were(57.78±15.45)%,(3.18±1.61)%,(51.09±12.26)%, (4.68±1.82)%,(20.25±7.45)%,(14.68±5.46)%(P<0.001). Conclusion The infectious mononucleosis can cause abnormal immune functions. The ratio of atypical lymphocytes, and NK cells numbers can be viewed as a monitoring index of the disease. Key words: Infectious mononucleosis; Lymphocyte subsets