2007肿瘤研究与临床Requires access

Effects of MMP-7 mRNA expression in esophageal cancer

廉建红, 王春利, 刘维兰, 杨瑞红, 郭素堂

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Abstract

目的 探讨食管癌患者外周血中基质活检因子(MMP-7)mRNA表达与食管癌复发及预后的关系.方法 采用实时荧光定量RT-PCR方法,检测82例食管癌术后患者外周血中MMP-7 mRNA表达.结果 82例食管癌患者中,MMP-7 mRNA表达阳性率为37.5%.MMP-7 mRNA表达阳性与淋巴结转移、血行转移和临床分期显著相关.28例复发患者中,15例接受动态观察,其中5例外周血中MMP-7 mRNA表达阳性先于影像学3~6个月,8例同时阳性.结论 食管癌患者外周血中MMP-7 mRNA表达阳性可作为食管癌转移、复发和预后判断的指标。

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What this paper is about

目的 探讨食管癌患者外周血中基质活检因子(MMP-7)mRNA表达与食管癌复发及预后的关系.方法 采用实时荧光定量RT-PCR方法,检测82例食管癌术后患者外周血中MMP-7 mRNA表达.结果 82例食管癌患者中,MMP-7 mRNA表达阳性率为37.5%.MMP-7 mRNA表达阳性与淋巴结转移、血行转移和临床分期显著相关.28例复发患者中,15例接受动态观察,其中5例外周血中MMP-7 mRNA表达阳性先于影像学3~6个月,8例同时阳性.结论 食管癌患者外周血中MMP-7 mRNA表达阳性可作为食管癌转移、复发和预后判断的指标。

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Available abstract

目的 探讨食管癌患者外周血中基质活检因子(MMP-7)mRNA表达与食管癌复发及预后的关系.方法 采用实时荧光定量RT-PCR方法,检测82例食管癌术后患者外周血中MMP-7 mRNA表达.结果 82例食管癌患者中,MMP-7 mRNA表达阳性率为37.5%.MMP-7 mRNA表达阳性与淋巴结转移、血行转移和临床分期显著相关.28例复发患者中,15例接受动态观察,其中5例外周血中MMP-7 mRNA表达阳性先于影像学3~6个月,8例同时阳性.结论 食管癌患者外周血中MMP-7 mRNA表达阳性可作为食管癌转移、复发和预后判断的指标。

Key concepts: Matrix metalloproteinase, Esophageal cancer, Messenger RNA, Cancer, Expression (computer science), Medicine, Cancer research, Biology

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