The correlation of the risk factors and the severity of the disease in patients with acute cerebral infarction

Objective To study the relationship between risk factors in patients of acute cerebral infarction and the severity of clinical disease.Methods Two hundred and seventy-two cases of patients with acute cerebral infarction whose onset time less than 24 h from Feb.2012 to Feb.2014,were collected as research subjects.Serf-designed questionnaire was used to collect the basic information and disease history of the research subjects.NIHSS score of 7 d after admission and mRS score regarded as comprehensive index of judging the severity of clinical disease.The NIHSS score of severe stroke group was 15 points or more (NIHSS ≥ 15 group),the NIHSS score of light stroke group was 15 points lower (NIHSS ＜ 15 group) ; the mRS score of severe stroke group was 3 points or more (mRS ≥ 3 group),the mRS score of light stroke group was 3 points lower(mRS ＜ 3 group).Results NIHSS score showed that there were statistically significant differences between NIHSS≥ 15 group and NIHSS ＜ 15 group in terms of age,white blood cell count(WBC),high-sensitivity c-reactive protein (hs-CRP),triglycerides (TG),total cholesterol (T-CHOL),TOAST stroke type of CE (TOAST CE),smoking history and drinking history (t =2.28,4.65,6.41,3.48,2.57,x2 =20.59,6.27,12.65 ; P ＜ 0.05).Multivariate logistic analysis showed that TOAST stroke type of CE (OR =0.122,95 ％ CI:0.034-0.426,P =0.001),smoking history (OR =9.021,95％ CI:1.808-45.017,P =0.007),the hs-CRP (OR =1.046,95％ CI:1.009-1.084,P =0.014),TG (OR =0.227,95％ CI:0.073-0.702,P =0.010) associated with NIHSS score of 7 d.mRS sorce showed that there were statisticallt significant differences between mRS ≥ 3 group and mRS ＜ 3 group in terms of age,the WBC count,hs-CRP,hyperlipemia,cerebral artery stenosis,TOAST stroke type of CE,history of smoking,drinking (t =4.26,5.12,4.12 respectively; x2 =13.30,4.56,4.96,15.00,6.48;P ＜ 0.05).Multivariate logistic analysis found that age (OR =2.751,95 ％ CI:1.375 -5.506,P =0.004),hyperlipidemia (OR =0.178,95％ CI:0.076-0.418,P ＜ 0.01),the WBC count (OR =2.404,95％ CI:1.222-4.731,P ＜ 0.01),the hs-CRP (OR =0.864,95％ CI:0.719-0.941,P =0.011),cerebral artery stenosis (OR =0.475,95％ CI:0.259-0.872,P =0.016) related with mRS score 7 d.Conclusion Age,hyperlipidemia,the WBC count,cerebral artery stenosis,TOAST stroke type of CE,smoking history,hs-CRP,high blood triglycerides are risk factors for acute cerebral infarction in a critical condition. Key words: Risk factors;  NIHSS score;  mRS score;  Acute cerebral infarction