2002•Unpublished venueRequires access

Effect of perioperative blood transfusion on T-cell subsets in patients with lung cancer

魏秀琴, 苏雷, 邓秀芝

Abstract

目的观察围术期输血对肺癌病人CD3、CD4、CD8、CD4/CD8的影响,对输血与机体免疫抑制的关系作一前瞻性的研究.方法对40例肺部肿瘤的病人随机分组,输血组病人在术中输血600 ml,测定、比较输血组与非输血组手术前后外周血T细胞亚群的变化.结果肺癌病人在术前的CD3、CD4、CD4/CD8明显低于良性肿瘤组(P＜0.05,P＜0.001,P＜0.001),输血组在术后表现为CD3、CD4/CD8的降低和CD8的明显升高(P＜0.05,P＜0.001,P＜0.005),与非输血组相比较差异均有显著意义(P＜0.01,P＜0.001,P＜0.001).结论肺癌病人的机体免疫功能处于抑制状态,T细胞亚群的测定能够反映这一状态的存在;围术期输血对肺癌病人的免疫功能有抑制作用.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Perioperative, Medicine, Lung cancer, Blood transfusion, Cancer, Intensive care medicine, Internal medicine, Oncology