Changes of retinal nervefiber layer thickness and its correlation with visual field mean defects in earlyParkinson's disease

：Objective To observe thechanges of retinal nerve fiber layer (RNFL) thickness and its correlation with visualfield mean defects(MD)in Parkinson's disease (PD). Methods Fifteen eyes of 15 PD patientsin early stage and 18 eyes of 18 normal controls undertook RNFL examination by StratusOCT-3. Circular scans (diameter is 3. 46 mm) were taken around the optic nerve headincluding eight quadrants (superior, inferior, temporal, nasal, temporal-superior,temporal-inferior, nasal-superior and nasalinferior). The RNFL thickness in differentquadrants in the two groups was analyzed. The visual field of PD patients was measured bycentral 30-2 program of Humphery750 visual field analyzer, and the MD was recorded. Thecorrelation between RNFL thickness and MD was analyzed by linear correlation andregression analysis. Results RNFL thicknesses of superior, inferior, temporal, nasal,temporal-superior, temporal-inferior, nasal-superior, nasal-inferior and average RNFLthickness in the control group were (132.7±17.4), (141. 5±15. 3),(83. 2±17. 5), (83.7±22.3),(120.8±21.2), (117. 9±24.5) ,(109.6±20. 6),(110.2±27.7), and(109. 9±8. 5) μm respectively, while in the PDgroup they were (128.1±25.3),(128. 6±13. 2),(68. 7±13. 5),(76. 5±17. 8),(102. 6±23.7), (103.3±14.1) ,(101.2±20.9),(96.6±15.0),(102.3±11.9) μm . Compared with each other, the differences of RNFLthickness of inferior, temporal, temporal-superior, temporal-inferior and average RNFLthickness were statistically significant (t = 2. 595, 2. 700, 2. 330, 2. 153,2. 131;P = 0.014, 0. 011, 0. 026, 0. 040, 0. 041). There was a close negative relationship betweenaverage RNFL thickness and MD in PD patients (r= -0. 933, P<0. 0001). Conclusions RNFLthickness was significantly thinner in PD patients than that in the normal controls. Therewas a negative relationship between RNFL thickness and MD in PD patients. Key words: Parkinson disease/diagnosis; Tomography,opticalcoherence/utilization; Perimetry/utilization