The clinical effect of pulmonary infection control window for sequence ventilation on treatment of severe pneumonia with respiratory failure

Objective To explore the clinical effect of pulmonary infection control window for sequence ven-tilation on treatment of severe pneumonia with respiratory failure, and to observe and analyze the prognosis. Methods 102 severe pneumonia patients complicated with respiratory failure were selected. They were divided into the observation group and the control group by the random number table method. The patients of the observation group were treated with pulmonary infection control window for sequence ventilation treatment, the control group were treated with conven-tional sequence ventilation treatment. The change of blood oxygen partial pressure(PaO2), carbon dioxide partial pres-sure(PaCO2) and blood oxygen saturation(SaO2)before and after ventilation, and the treatment time and symptoms improve time and the complications such as ventilator associated pneumonia(VAP)of the two groups were observed. Results PaO2 and SaO2 of the observation group after the ventilation were(75.60±2.89)mmHg and(0.78±0.09), which were higher than control group after the ventilation(70.48±3.16)mmHg and(0.71±0.11),and data of two groups after ventilation were higher than those before the treatment, differences were statistically significant(t＝11.30,10.92,13.26,14.08,all P＜0.05).PaCO2 of the observation group after the ventilation was 49.21±3.22 mmHg, which was lower than that of control group after the ventilation of 54.35±3.82 mmHg, and data of two groups after treatment was lower than before treatment, the differences were statistically significant(t＝12.44,11.85,14.16,13.42,all P＜0.05). The total mechanical ventilation time of the observation group, respiratory difficulty relief time, lung then disappear time and hospital stay time were(5.24±1.83)d,(38.13±2.91)h,(6.72±0.40)d and (15.33±3.18)d, which were lower than those of control group, the differences were statistically significant(t＝9.87,10.21,10.46,11.08,all P＜0.05). The general adverse reaction and the death rate of the observation group was 9.80%(5／51), which was lower than 19.61% of the control group(χ2＝9.85,P＜0.05). Conclusion There was effect of pulmonary infection control window for sequence ventilation treatment of severe pneumonia with respirato-ry failure, and it could improve effectively lung function and the prognosis and reduce the incidence of complications. Key words: Pneumonia; Respiratory Insufficiency; Time Factors; Ventilators, Mechanical