Clinical observation of two kinds of corneal refractive surgery in the treatment of high myopia

Objective Comparison of femtosecond laser assisted laser in situ keratomileusis (FS-LASIK) and microkeratome flap excimer laser in situ keratomileusis (MM-LASIK) clinical efficacy and safety of high myopia in two kinds of surgical methods to correct. Methods The clinical data of 454 patients (908 eyes) with high myopia treated by laser in situ keratomileusis(LASIK) in Shanxi eye hospital from January 2013 to January 2016 were collected. According to the different surgical methods, all patients were divided into FS-LASIK group and MM-LASIK group. Among them, 312 cases (624 eyes) of FS-LASIK group, 142 cases (284 eyes) of MM-LASIK group. The uncorrected visual acuity (UCVA), the best corrected visual acuity (BCVA), the safety index, the validity index, the refractive index, and the intraocular pressure (IOP) were measured before and after 1 months, at the end of the 3 month, and at the age of 1 months. Before and after the operation of UCVA, BCVA, spherical equivalent, intraocular pressure, effectiveness index and safety index with the mean standard deviation of that used before and after surgery postoperative self controlled study design, UCVA, effectiveness index and safety index comparison between groups and different time points within groups were compared using two factor repeated measurement and analysis of variance, 22 different time points were compared by LSD-t test. Results There was significant difference in spherical equivalent between the 2 groups (t=-3.37, P<0.05). There were significant differences in UCVA between the 2 groups at different time points before and after operation (Ftime=12773.28, P<0.05). There were significant differences in the safety index between the 2 groups at different time points (Ftime=28.50, P<0.05). There was a significant difference between the 2 groups in the overall safety index (Fgroup=7.52, P<0.05). There was a significant difference between the 2 groups in different time points after operation (Ftime=20.02, P<0.05). There was a significant difference between the 2 groups (Fgroup=4.48, P<0.05). Conclusions FS-LASIK and MM-LASIK are safe and effective methods for treatment of high myopia. After FS-LASIK, the visual acuity recovered more quickly, and the safety and effectiveness of each point in the 1 year after operation was better than that of MM-LASIK. Key words: Femtosecond laser; Keratomileusis; Laser in situ; High Myopia