Effect of gene regulation in pathogenesis of biliary atresia

Biliary atresia (BA) is a common neonatal liver disease characterized by inflammation and fibrosis of the extrahepatic biliary ducts, leading to cholestasis and biliary cirrhosis.It is also a severe liver disease in infants.The pathogenesis of BA is associated with multiple genes and gene polymorphism, virus infections, epigenetic, immune abnormalities, and so on.With the development of genetic technology, it provides a new method to determine the susceptibility genes in BA.Now, more and more doctors pay attention to the change and regulation of genes in BA. Key words: Biliary atresia; Gene; Child