2017•Zhonghua weishengwuxue he mianyixue zazhiRequires access

Antibodies and vaccines against glycoprotein of Marburg virus

Li Zhang, Qianqian Li, Weijin Huang

Abstract

Marburg virus (MARV) is a lethal virus that causes fatal hemorrhagic fever. It belongs to the Filoviridae family which also includes Ebola virus. MARV is similar to Ebola virus in structure and infection mechanism. Moreover, the diseases caused by them have similar clinical symptoms. However, researches on MARV are less than those on Ebola virus. In this review, we focus on the viral structure, especially the structure of MARV glycoprotein (GP) which determines its infectivity, functions of MARV GP as well as protective antibodies and vaccines against this protein. Key words: Marburg virus; Glycoprotein; Protein structure; Protective antibody; Vaccine

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Key concepts: Marburg virus, Filoviridae, Virology, Ebola virus, Antibody, Glycoprotein, Virus, Infectivity