2013•Chin Arch Gen Surg(Electronic Edition)Requires access
Clinical significance of lymph node micrometastasis detection in determining the stage of gastric cardia adenocarcinoma
Luo Zhang, Qing Li, Fan-xian Ouyang, Zhigang Lin
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Abstract
Objective
To evaluate the significance of lymph node micrometastasis in determining the stage of gastric cardia adenocarcinoma(GCA).
Methods
Three hundred and twenty-three lymph nodes from 48 GCA patients with negative lymph node by routine pathological examination were examined immunohistochemically(IHC) for the lymph nodes micrometastasis using anti-CK19 and anti-CD44v6 monoclonal anti-body. Clinical data were analyzed by statistical methods.
Results
Micrometastasis was found in 14 lymph nodes (4.33%) from 9 cases (18.75%). Nine of those patients were up-staged(from stageⅠA toⅠB in one patient, stageⅠB to ⅡA in three patients, stageⅡA to ⅡB in three patients, stageⅡA to ⅢA in one patient, stageⅡB to ⅢB in one patient). The rate of restaging was 18.75%.
Conclusion
IHC assay can increase the detection rate of lymph node metastasis and has a significant impact on the staging of GCA.
Key words:
Gastric cardia adenocarcinoma; Lymph node; Micrometastasis; Neoplasm staging