2012•Zhonghua weishengwuxue he mianyixue zazhiRequires access
Molecular characteristics of the hemagglutinin and neuraminidase of influenza B viruses isolated in Jiangsu province, 2011
Wei Li, Pengfei Luo, Fēi Dèng, Yuanfang Qin, Hairong Zi, Fenyang Tang, Xian Qi, Pingmin Wei
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Abstract
Objective To characterize the molecular characteristics of hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses isolated in Jiangsu province,2011.Methods Thirteen strains of influenza B virus in different areas and epidemic period in Jiangsu province,2011 were selected for whole-genome sequencing,and analysis of molecule epidemic characteristics for HA and NA was carried out by bioinformatics method.Results Of the 13 randomly selected influeuza B strains,10 strains were assorted to Victoria lineage strains with NA genes from Yamagata lineage,and 3 strains belong to Yamagata lineage.Compared nucleotide and amino acid sequences of HA and NA genes with their vaccine strains respectiuely,196/197 glycosylation site appeared on HA1 gene in Yamagata/Victoria isolates virus.Conclusion Both B/Victoria and B/Yamagata lineage viruses co-circulated in Jiangsu province,and reassortant virus of Victoria lineage were predominant virus.
Key words:
Influenza B; Hemagglutinin; Neuraminidase; Molecular characteristics