Pathological study on cerebral amyloid angiopathy hemorrhage

Objective To study the prevalence and neuropathological characteristics of cerebral amyioid angiopathy hemorrhage( CAAH )in spontaneous intracerebral hemorrhage( SICH ) patients of Xinjiang minority areas.Methods From May 2009 to March 2011,124 patients admitted to six hospitals throughtout Xinjiang for acute SICH.The patients were suffered from SICH proved by computed tomography scan(CT).Emergent craniotomy for hemorrhage evacuation were performed for those patients within 72 h after hemorrhage onset and brain tissue around the hematoma was also obtained for histological examination through HE dyed 、Congo Red stained under polarized light microscope and Aβ immunochemistry to verify the existence of CAA.Results 11 patients were identified as CAAH and the total ratio was 8.9％.Among which 4 cases were congophilic angiopathy,1 plaque - like angiopathy,6 mixed type.Conclusions 8.9％SICH are associated with CAA in Xinjiang minority areas.The vessel walls of CAA become thickening and the normal vessel structures disappear.β -amyloid protein is mainly deposited in small arteries,middle and outer membrane.In some patients,β -amyloid protein is deposited in brain. Key words: Cerebral amyloid angiopathy;  Spontaneous intracerebral hemorrhage;  Pathology