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2014•Guoji shuxue ji xueyexue zazhiRequires access

Clinical Applications and Advances of Thrombopoietin Receptor Agonist

Yang Li

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Abstract

Thrombocytopenia is a common clinical disorder,which could be found in hematological and non-hematological diseases.With significant advances in thrombopoietic agents,the application of thrombopoietin receptor agonist (TPORA),romiplostim and eltrombopag,could effectively increase the platelet count of patients,and provide a new treatment for thrombocytopenia.This article review the literatures on the mechanisms and clinical use of TPORA in hematological disorders and thrombocytopenia related to hepatopathy. Key words: Thrombopoietin receptor agonists;  Romiplostim;  Eltrombopag; Thrombocytopenia ;  Drug therapy

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What this paper is about

Thrombocytopenia is a common clinical disorder,which could be found in hematological and non-hematological diseases.With significant advances in thrombopoietic agents,the application of thrombopoietin receptor agonist (TPORA),romiplostim and eltrombopag,could effectively increase the platelet count of patients,and provide a new treatment for thrombocytopenia.This article review the literatures on the mechanisms and clinical use of TPORA in hematological disorders and thrombocytopenia related to hepatopathy. Key words: Thrombopoietin receptor agonists;  Romiplostim;  Eltrombopag; Thrombocytopenia ;  Drug therapy

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Available abstract

Thrombocytopenia is a common clinical disorder,which could be found in hematological and non-hematological diseases.With significant advances in thrombopoietic agents,the application of thrombopoietin receptor agonist (TPORA),romiplostim and eltrombopag,could effectively increase the platelet count of patients,and provide a new treatment for thrombocytopenia.This article review the literatures on the mechanisms and clinical use of TPORA in hematological disorders and thrombocytopenia related to hepatopathy. Key words: Thrombopoietin receptor agonists;  Romiplostim;  Eltrombopag; Thrombocytopenia ;  Drug therapy

Key concepts: Eltrombopag, Romiplostim, Thrombopoietin receptor, Thrombopoietin, Medicine, Agonist, Platelet, Pharmacology

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