2019•Unpublished venueRequires access
Clinical characteristics of gastrointestinal involvement in polyarteritis nodosa
Xiaocong Huo, Miao Li, Jiaxin Zhou, Di Wu, Jing Li, Dong Xu, Xinping Tian, Fengchun Zhang, Xiaofeng Zeng
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Abstract
Objective
To investigate the clinical characteristics of gastrointestinal involvement in polyarteritis nodosa (PAN), and to improve the understanding of the disease.
Methods
PAN patients hospitalized in Peking Union Medical College Hospital from March 2002 to September 2016 were enrolled in this study, and were divided into gastrointestinal involvement group and non-gastrointestinal involvement group according to clinical manifestations and imaging findings. Data on clinical features, treatments and outcome were recorded. t test, chi-square test were used for statistical analysis.
Results
A total of 117 patients with PAN were hospitalized in the past 14 years. The prevalence of gastrointestinal involvement was 38%(44 cases). There was no significant difference in age and sex between the two groups (P>0.05). Abdominal pain (29 cases, 66%) was the most frequent manifestation, then gastrointestinal bleeding (10 cases, 23%), splenic infarction(3 cases, 7%), gastrointestinal ulcers (2 cases, 5%), intestinal obstruction or diarrhea (each 2 cases, 5%), and vomiting (1 case, 2%). Patients with gastrointestinal involvement had more frequent fatigue (27% vs 11%;χ2=5.156, P=0.023), increased diastolic pressure (55% vs 34%; χ2=4.647, P=0.031), renal (34% vs 18%;χ2=3.998, P=0.046) and cardiac (25% vs 8%; χ2=6.225, P=0.013) involvements. ESR in the gastrointestinal involvement group was significantly higher(75% vs 56%; χ2=4.190, P=0.041). The average follow-up time was 315.8 (20.3, 441.3) days, the relapse rate was higher in the gastrointestinal involvement group (23% vs 8%; χ2=4.895, P=0.027) . The incidence of death or the irreversible organ injury was higher in the gastrointestinal involvement group (27% vs 11%, χ2=5.156, P=0.023) .
Conclusion
Gastrointestinal invol-vement in poly-arteritis nodosa is common and its condition is severe. The incidence of relapse and death or irreversible organ injury is high.
Key words:
Polyarteritis nodosa; Gastrointestinal tract; Signs and symptoms, digestive