The effect of dyslipidemia on laparoscopic Roux-en-Y gastric bypass for type 2 diabetes mellitus

Objective To compare the effects of laparoscopic Roux-en-Y gastric bypass(LRYGB) for the treatment of type 2 diabetes mellitus(T2DM) patients with/withou dyslipidemia. Methods A total of 36 T2DM patients undergoing LRYGB were enrolled in this study in our hospital from June 2012 to June 2014.The mean age was 42.4±11.5, and the mean body mass index (BMI) was (32.8±4.5)kg/m2 before surgery. Patients were divided into dyslipidemia group (n=22) and normal group (n=14). Clinical data of the two groups were compared 12 months after surgery. Results All the patients were successfully operated, and followed up for minimum of 12 months. In dyslipidemia patients BMI decreased from (33.5±5.2)kg/m2 to (26.8±3.9)kg/m2 12 months after surgery, fasting blood glucose decreased from (8.6±1.8)mmol/L to (5.6±1.2)mmol/L (t=7.707, P=0.000), and HbA1c decreased from (7.8%±1.3%) to ( 6.1%±1.0%)(t=8.186, P=0.000); In ortholiposis group BMI decreased from (31.6±2.8)kg/m2 to (27.4±3.3)kg/m2, as fasting blood glucose decreased from (8.3±1.5)mmol/L to (6.1±1.6)mmol/L(t=4.564, P=0.001), and HbA1c decreased from (7.4%±1.8%) to (6.5%±0.9%)(t=1.827, P=0.091). Homa-IR in both groups significantly improved after surgery (8.0±5.8) vs. (2.2±3.2), (t=5.979, P=0.000); (8.1±6.1) vs. (2.2±1.9), (t=3.528, P=0.004). Complete remission ratio as well as glucose and HbA1c changes 1 year after surgery were without differences between the two groups. Conclusion Preoperative blood fat status exerts no significant effect on the prognosis of T2DM patients undergoing laparoscopic Roux-en-Y gastric bypass. Key words: Diabetes mellitus, type 2; Anastomosis, Roux-en-Y; Dyslipidemia