Clinical characteristics and prognostic analysis of lung adenocarcinoma

Objective To investigate the clinicopathological characteristics and prognosis of lung adenocarcinoma undergoing resection, and explore the its prognostic factors. Methods The clinical data of 109 cases of lung adenocarcinoma undergoing resection were retrospectively reviewed. Univariate analysis of clinicopathological characteristics was performed, and the statistically significant factors were included in multivariate analysis. Results For the 109 cases of lung adenocarcinoma, the overall 5-year survival was 44.0%(48/109). Univariate analysis revealed that tumor size(χ2=8.995, P=0.003), lymph node status(χ2=12.727, P=0.0000), TNM stage(χ2=39.544, P=0.000), surgical margin(χ2=35.551, P=0.000)and expression of PCNA(χ2=5.441, P=0.020) influenced survival time. Multivariate analysis indicated that tumor size, TNM stage, and surgical margin were independent prognostic factors of lung adenocarcinoma (P<0.05), and postoperative chemotherapy was prognostic factors of stageⅡ and Ⅲ lung adenocarcinoma(χ2=11.299, P=0.001). Conclusion Tumor size, higher TNM stage and positive surgical margin may be important factors of unfavorable prognosis of lung adenocarcinoma, and patients with stage Ⅱ and Ⅲ lung adenocarcinoma may gain benefits from postoperative adjuvant chemotherapy. Key words: Lung neoplasm; Lung adenocarcinoma; Univariate analysis; Multivariate analysis; prognosis