2017•Zhonghua weishengwuxue he mianyixue zazhiRequires access
Progress in IL-36 as a new target for the treatment of inflammatory diseases
Xiaoying Wang, Zhiyu Lu, Keye Xu, Mingcai Li
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Abstract
Interleukin (IL)-36, a member of the IL-1 family, plays an important role in mediating inflammatory diseases. IL-36 subfamily consists of IL-36α, IL-36β, IL-36γ and IL-36 receptor antagonists (IL-36Ra). IL-36 receptor (IL-36R) and IL-1 receptor accessory protein (IL-1RAcP) are involved in the IL-36-mediated signal transduction. In human, mutations in the gene encoding IL-36Ra will lead to IL-36R signaling disorders, mainly manifested as diffuse pustular psoriasis. It suggests that IL-36 plays an important role in psoriasis. Recently, it has also been found that IL-36 is related to inflammation in other organs. These emerging roles of IL-36 provide new thoughts for the treatment of human inflammatory diseases.
Key words:
Interleukin-36; Inflammation; Psoriasis; Inflammatory bowel disease