Application of magnetic source imaging and electroneurophysiology in glioma surgery near eloquent areas

Objective To investigate the value of applying magnetic source imaging (MSI) and electroneurophysiology in glioma surgery near eloquent areas.Methods 23 patients with gliomas near eloquent areas underwent MSI to localize sensorimotor and speech cortex,and had resection of the lesions combining with neuronavigation.6 patients had localization of central sulcus with SEP-PR,and had corti-subcortical dectrical stimulation to preserve motor area and pyramidal tract.Results Total resection was achieved in 12 patients,subtotal in 8,and partial in 3.6 patients had transient postoperative neurological disorders.Only one case suffered from permanent deficits.The distance (MSI-Tumor) was associated with postoperative neurological disorders(transient or permanent) (P =0.001).Conclusions MSI could provide the relationship between glioma and eloquent areas.It is helpful for the risk evaluation of glioma surgery and surgical plans.When the glioma is closely correlated with eloquent areas,accurate localization of eloquent areas combined with intraoperative electroneurophysiology could be achieved to guide the extent of resection. Key words: Magnetoencephalography;  Functional mapping;  Electrical stimulation; Somatosensory evoked potentials;  Magnetic source imaging;  Glioma