Influence of continuous veno venous hemofiltration therapy on serum levels of cytokines in Children with multiple organ dysfunction syndromes

Objective To investigate the effects of continuous veno-venous hemofiltration therapy (CVVH) on the serum cytokines level in children with sepsis (Sepsis) and multiple organ dysfunction syndromes (MODS). Methods 15 cases of MODS were given CVVH treatment addition with the basis treatment, such as antibiotics, vasoactive drugs, nutritional support therapy, the maintenance of water quality of acid-base balance, and mechanical ventilation. Serum levels of cytokines TN F-α, IL-1, IL-6 were measured at 0h, 24h and 48h. According to the result, 15 cases were divided into the survival group and the death group, and compared with serum levels of cytokines TNF- α, IL-1, IL-6 of two groups, the number of organ MODS, PCIS , time of onset to CVVH and the total time of CVVH were compared. Results TNF- α was decreased at 24h and 48h, IL-1 was decreased at 48h, IL-6 was decreased at 24hand 48h , the difference was significant (P 0.05). The average number of organs of death group was higher than that of survival group, PCIS lower than the survival group the difference was significant (P 0.05).Conclusion CVVH can quickly and effectively remove the cytokines , CVVH treatment can improve the prognosis and survival rate if used as early as possible. Key words: Continuous veno-venous hemofiltration;  Multiple organ dysfunction syndromes; Children;  Cytokines