Progress of lymphomatoid granulomatosis

Lymphomatoid granulomatosis (LG) is a kind of Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease. Pathologically, it is characterized by angioinvasion and large EBV-positive atypical B cells in an inflammatory background with numerous T cells. Clinically, it mainly involves the bilateral lungs in the mid and lower lung fields, extra-pulmonary sites such as central nervous system, skin have also been reported. There are still no uniform treatment protocols about the disease, and pathological grading is a main reference. Overall, the prognosis is poor. Because of the rarity, lack of typical symptoms and special imaging characteristics, LG was often misdiagnosed. The article summarizes the diagnosis, treatment and prospects of LG to improve the clinician's understanding of the disease. Key words: Lymphomatoid granulomatosis; Diagnosis; Treatment