2003•实用儿科临床杂志Requires access

Study on loss-expression of P73 gene in childhood acute lymphoblasic leukemia

殷小成, 曹励之, 邓晖, 王颖超, 张朝霞

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Abstract

目的探讨P73mRNA失表达在小儿急性淋巴细胞白血病(ALL)中的临床意义. 方法 RT-PCR法检测40例ALL患儿骨髓单个核细胞内P73mRNA表达,并分析P73mRNA失表达与影响ALL预后因素的关系.结果 ALL中存在较高频率的P73mRNA失表达,且与高白细胞数、高肿瘤负荷、髓外浸润、高危临床分型显著相关.结论 P73mRNA失表达在小儿ALL发病过程中起重要作用,P73mRNA失表达与预后不良因素相关,P73mRNA检测可能对评估小儿ALL预后、指导临床治疗有重要意义.

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目的探讨P73mRNA失表达在小儿急性淋巴细胞白血病(ALL)中的临床意义. 方法 RT-PCR法检测40例ALL患儿骨髓单个核细胞内P73mRNA表达,并分析P73mRNA失表达与影响ALL预后因素的关系.结果 ALL中存在较高频率的P73mRNA失表达,且与高白细胞数、高肿瘤负荷、髓外浸润、高危临床分型显著相关.结论 P73mRNA失表达在小儿ALL发病过程中起重要作用,P73mRNA失表达与预后不良因素相关,P73mRNA检测可能对评估小儿ALL预后、指导临床治疗有重要意义.

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Available abstract

目的探讨P73mRNA失表达在小儿急性淋巴细胞白血病(ALL)中的临床意义. 方法 RT-PCR法检测40例ALL患儿骨髓单个核细胞内P73mRNA表达,并分析P73mRNA失表达与影响ALL预后因素的关系.结果 ALL中存在较高频率的P73mRNA失表达,且与高白细胞数、高肿瘤负荷、髓外浸润、高危临床分型显著相关.结论 P73mRNA失表达在小儿ALL发病过程中起重要作用,P73mRNA失表达与预后不良因素相关,P73mRNA检测可能对评估小儿ALL预后、指导临床治疗有重要意义.

Key concepts: Childhood leukemia, Leukemia, Gene, Gene expression, Expression (computer science), Genetics, Biology, Cancer research

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