Clinical study of the influence of blood pressure variability on cardiac structure and renal injury in patients with senile essential hypertension

Objective To investigate the influence of blood pressure variability (BPV) on cardiac structure and renal injury in patients with senile essential hypertension. Methods Two hundred patients with essential hypertension were divided into two groups according to decreasing rate of blood pressure in night. The patients with <10% decreasing rate of blood pressure were allocated into non-dipper group and ≥10% into dipper group, which were matched in age and gender. Ambulatory blood pressure monitoring and echocardiography were performed in all of them. Results 24 h SBP、24 h DBP、night SBP (nSBP) and night DBP (nDBP) were significantly higher in non-dipper group than those in dipper group. Night BPV was significantly higher in non-dipper group than those in dipper group. Left ventricular mass index was higher in non-dipper group than those in dipper group. Most of finding rate of a series microproteinuria was significantly higher in non-dipper group than those in dipper group. Conclusions Non-dipper circadian rhythm could induce the decrease of renal function and increase of left ventricular hypertrophy in patients with essential hypertension. Key words: Hypertension;  BPV;  Blood pressure monitoring;  Left ventricular hypertrophy;  β2-Microglobulin;  24-hour urinary mAlb