武卫华, 武培敬, 陈海霞, 许艳梅, 韩庶永
Abstract
目的:探讨大肠腺癌组织中CD44v6、p27蛋白表达的意义.方法:应用免疫组化S-P法检测大肠腺癌中CD44v6、p27蛋白表达.结果:60例大肠腺癌中CD44v6、p27蛋白表达总阳性率分别为57%(34/60)、22%(1 3/60);两者阳性表达与大肠癌组织分化程度及浸润深度无明显相关性(P＞0.05),而与淋巴结转移及预后显著相关(P＜0.05);CD44v6阳性表达与大肠癌淋巴结转移呈正相关,与预后呈负相关,p27阳性表达与之相反.结论:CD44v6、p27蛋白表达与大肠腺癌转移及预后相关,联合检测CD44v6、p27蛋白表达水平,对判断大肠癌恶性程度、复发转移潜能,评估患者预后及术后选择合理治疗方案有一定参考价值.
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目的:探讨大肠腺癌组织中CD44v6、p27蛋白表达的意义.方法:应用免疫组化S-P法检测大肠腺癌中CD44v6、p27蛋白表达.结果:60例大肠腺癌中CD44v6、p27蛋白表达总阳性率分别为57%(34/60)、22%(1 3/60);两者阳性表达与大肠癌组织分化程度及浸润深度无明显相关性(P＞0.05),而与淋巴结转移及预后显著相关(P＜0.05);CD44v6阳性表达与大肠癌淋巴结转移呈正相关,与预后呈负相关,p27阳性表达与之相反.结论:CD44v6、p27蛋白表达与大肠腺癌转移及预后相关,联合检测CD44v6、p27蛋白表达水平,对判断大肠癌恶性程度、复发转移潜能,评估患者预后及术后选择合理治疗方案有一定参考价值.
Key concepts: Colorectal adenocarcinoma, Expression (computer science), Adenocarcinoma, Medicine, Internal medicine, Computer science, Cancer, Programming language