Relationship of serum ANGPTL4 to obesity and type 2 diabetes mellitus

Objective To investigate the level of serum angiopoietin-like protein 4 （ ANGPTIA ） in normal subjects and patients with obesity and newly-diagnosed type 2 diabetes mellitus （ T2DM）, and to explore the relationship of serum ANGPTL4 with parameters of body fat, glucose-lipid metabolism, and insulin resistance index （ HOMA-IR）. Methods A total of 160 subjects with normal glucose regulation（NGR） and newly-diagnosed T2DM, were divided into 4 groups ： NGR with normal weight group （ NGR-NW ） , NGR with overweight/obese group （ NGR- OW/OB） , rF2DM with normal weight group （T2DM-NW）, and T2DM with overweight/obesity group （T2DM-OW/ OB） according to their body mass index （BMI）. ELISA was used to determine the level of serum ANGPTIA. The weight, height, waist circunfferenee, hip circumference, waist hip ratio （WHR） , and BMI, fasting insulin （ FINS ） , lipid metabolism parameters, and insulin resistance index （HOMA-IR） were measured. Results Compare with the NGR group, the level of ANGFFIA was significantly decreased in the T2DM group [ （ 25.75 ± 2.85 vs 31.08± 3.35 ） ng/ml, P〈0.01 ], the level of ANGPTIA in OW/OB group was significantly lower than that in the NW group [ （ 27.27 ±3.05 vs 29.04 ± 4.64） ng/ml, P〈0.01 ]. Partial correlation analysis showed that serum ANGPTIA was negatively correlated with BMI, WHR, FPG, 2hPG, HbA1C, FINS, HOMA-IR, AST, ALT, and TG levels（P〈0.01 ）, but positively correlated with the HDL-C （ P〈0.01 ）. Multiple stepwise regression analysis showed that HbA1C, FINS, and HDL-C were independent risk factors of serum ANGPTIA （β = -0. 825, -0. 119, 3. 301, P〈0.01 ）. Conclusion Sernm ANGPT1A level in T2DM and OW/OB group was lower than that in NGR and NW group. Serum ANGPTIA is associated with FINS and lipid metabolism, suggesting that it may play an important role in the pathophysiology of obesity and metabolic syndrome. Key words: A ngiopoietin-like protein 4 ;  Lipid metabolism disorders ;  Insulin resistance ;  Diabetes mellitus,type 2