The level and clinical value of serum interleukin-12 and interleukin-4 in children with pneumonia
季钗, 潘滔, 陈黎勤
Abstract
季钗, 潘滔, 陈黎勤
Abstract
目的观察肺炎儿白细胞介素12(IL-12)、白细胞介素4(IL-4)的变化,探讨其在小儿肺炎发生、发展的作用。方法采用酶标记免疫双抗体夹心法,定量监测肺炎急性期、恢复期、对照组血清IL-12、IL-4水平。结果肺炎急性期组、恢复期组、对照组血清IL-12、IL-4、IL-12/IL-4比值差异有显著性,IL-12、IL-12/IL-4以急性期组最高,对照组最低,IL-4则反之,急性期组IL-12与IL-4无直线相关(n=31 r=-0.1237)。结论动态观察血清IL-12、IL-4水平变化,对判断疗效、指导临床合理用药有一定价值。
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目的观察肺炎儿白细胞介素12(IL-12)、白细胞介素4(IL-4)的变化,探讨其在小儿肺炎发生、发展的作用。方法采用酶标记免疫双抗体夹心法,定量监测肺炎急性期、恢复期、对照组血清IL-12、IL-4水平。结果肺炎急性期组、恢复期组、对照组血清IL-12、IL-4、IL-12/IL-4比值差异有显著性,IL-12、IL-12/IL-4以急性期组最高,对照组最低,IL-4则反之,急性期组IL-12与IL-4无直线相关(n=31 r=-0.1237)。结论动态观察血清IL-12、IL-4水平变化,对判断疗效、指导临床合理用药有一定价值。
Key concepts: Medicine, Pneumonia, Interleukin, Immunology, Value (mathematics), Interleukin 15, Internal medicine, Cytokine