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Experimental study on microvessel density in brain astrocytoma and its significance

平金良, 章步文

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Abstract

目的 观察脑星形细胞瘤组织中微血管密度(MVD),分析其与临床病理特征及与预后的关系.方法采用免疫组织化学方法,检测52例脑星形细胞瘤组织中微血管生成情况.结果脑星形细胞瘤组织中MVD为71.8±27.8,高于正常脑组织25.8±6.2,差异有显著性(P＜0.01);高级别脑星形细胞瘤中(Ⅲ,Ⅳ级)MVD为81.7±26 9,显著高于低级别(Ⅰ,Ⅱ级)52.8±18.4,差异有统计学意义(P＜0.01);术后复发死亡患者MVD高于未复发死亡患者(P＜0.01).结论MVD反映瘤组织内血管生成状态,与肿瘤的组织级别密切相关,可作为脑星形细胞瘤预后指标。

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目的 观察脑星形细胞瘤组织中微血管密度(MVD),分析其与临床病理特征及与预后的关系.方法采用免疫组织化学方法,检测52例脑星形细胞瘤组织中微血管生成情况.结果脑星形细胞瘤组织中MVD为71.8±27.8,高于正常脑组织25.8±6.2,差异有显著性(P＜0.01);高级别脑星形细胞瘤中(Ⅲ,Ⅳ级)MVD为81.7±26 9,显著高于低级别(Ⅰ,Ⅱ级)52.8±18.4,差异有统计学意义(P＜0.01);术后复发死亡患者MVD高于未复发死亡患者(P＜0.01).结论MVD反映瘤组织内血管生成状态,与肿瘤的组织级别密切相关,可作为脑星形细胞瘤预后指标。

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Available abstract

目的 观察脑星形细胞瘤组织中微血管密度(MVD),分析其与临床病理特征及与预后的关系.方法采用免疫组织化学方法,检测52例脑星形细胞瘤组织中微血管生成情况.结果脑星形细胞瘤组织中MVD为71.8±27.8,高于正常脑组织25.8±6.2,差异有显著性(P＜0.01);高级别脑星形细胞瘤中(Ⅲ,Ⅳ级)MVD为81.7±26 9,显著高于低级别(Ⅰ,Ⅱ级)52.8±18.4,差异有统计学意义(P＜0.01);术后复发死亡患者MVD高于未复发死亡患者(P＜0.01).结论MVD反映瘤组织内血管生成状态,与肿瘤的组织级别密切相关,可作为脑星形细胞瘤预后指标。

Key concepts: Astrocytoma, Medicine, Glioblastoma, Cancer research

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