Neoadjuvant chemotherapy plus concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma

Nasopharyngeal Carcinoma is one of the most common malignancy in the southern area of China, most patients were locally advanced nasopharyngeal carcinoma (LANPC) when di-agnosed. Since Nasopharyngeal Carcinoma (NPC) is sensitive to both radiotherapy and chemothera-py, concurrent chemoradiotherapy (CCRT) was considered to be the primary treatment for NPC in past years. Nevertheless, induction chemotherapy plus concurrent chemoradiotherapy (IC+CCRT) was revealed to be more effective. Compared with traditional radiotherapy (RT), intensity-modulated radiotherapy (IMRT) has driven the improvement in tumour control and reduction in toxic effects in patients. By comparing traditional radiotherepy with intensity-modulated radiotherapy for locally advanced, the article aims to review the therapeutic effects of concurrent chemoradio-therapy and introduction chemotherapy plus concurrent chemoradiotherapy. Key words: Nasopharyngeal Neoplasms; induction chemotherapy; Radiotherapy, Intensity-Modulated