Epilepsy surgery in infants

Objective To investigate the etiology of intractable epilepsy in infants, and to study the surgical indications, procedures and clinical outcomes of epilepsy surgery in infants with intractable epilepsy. Methods Between 2000 and 2008, the etiology, surgical indications, procedures and clinical outcomes of epilepsy surgery in 54 infants were retrospectively analyzed. Results Malformation of cortical development and cortical dysplasia were the predominant causes of pediatric intractable epilepsy. After surgery, all patients were followed up for 3 years in average. The surgical efficacy was evaluated using Eagel criterion: Engel Class I was achieved in 18 patients, Engel ClassⅡ in 15 (rare seizure), and Engel Class III in 13 (less frequent seizures). The intellectual ability was assessed using Gesell developmental quotient (DQ). Most patients' intellectual abilities were improved 1-2 years' after surgery. Conclusions Surgery is a good option for the infants with intractable epilepsy, especially for the patients with delayed intelectual ability development. Key words: Epilepsy;  Neurosurgical procedures