Detection of pathogenic bacteria and analysis of drug resistance in patients with abdominal infection

Objective To analyze the detection and drug resistance of pathogenic bacteria in patients with abdominal infection. Methods The clinical data of patients with abdominal infection admitted to our hospital from January 2016 to December 2018 were retrospectively analyzed. Peritoneal specimens were collected and pathogenic bacteria culture and drug sensitivity test were carried out. Results A total of 4 629 samples were sent for examination, 540 of which were cultured positive, with a positive rate of 11.67%. There were 582 strains of pathogenic bacteria, including 355 strains of Gram-negative bacteria, 201 strains of Gram-positive bacteria, and 26 strains of fungi. Escherichia coli and Klebsiella pneumoniae were more resistant to third-generation cephalosporins than to carbapenems, amikacin, and tigecycline. The resistance rates of Acinetobacter baumannii to many commonly used antimicrobial agents were at a high level, and the resistance of Pseudomonas aeruginosa to commonly used antimicrobial agents were low. Enterococcus faecium was more resistant to penicillin and ciprofloxacin, less resistant to vancomycin and linezolid, and Enterococcus faecalis was less resistant to commonly used antimicrobial agents. Staphylococcus aureus and Staphylococcus epidermidis were both more resistant to penicillin and third-generation cephalosporins. Conclusion There are many kinds of pathogenic bacteria in patients with abdominal infection, and the drug resistance of pathogenic bacteria is severe. We should actively carry out bacterial culture and drug sensitivity test in clinic to understand the distribution and drug resistance of pathogenic bacteria, and rationally select antibiotics. Key words: Abdominal infection; Pathogenic bacteria; Detection; Drug resistance