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2015•Zhongguo jiceng yiyaoRequires access

Association of polymorphisms in angiotensin II receptor gene with primary aldosteronism

Fu-Man Du, Weimin Wang, Binhong Duan, Chaofeng Xiang

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Abstract

Objective To investigate the relationship between the polymorphisms of angiotensin Ⅱ receptor gene and the risk of primary aldosteronism (PA). Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine the 1166A/C polymorphism of AT1R gene and 1675A/G polymorphism of AT2R gene in 85 patients with PA and 100 healthy controls. Results There was no significant difference of AT1R 1166A/C genotypes (AA, AC, CC) and allele (A and C) frequency among patients and controls (χ2=0.430, P=0.806).There was obvious difference of AT2R 1675A/G genotypes (AA, AG, GG) and allele (A and G) frequency among two groups (χ2=6.121, P=0.013).The G allele was higher than A allele in PA group (χ2=6.767, P=0.009). Conclusion Homogenic mutation of 1675A/G site in AT2R gene may be one of risk factors of PA. Key words: Hyperaldosteronism; Receptor, angiotensin, type 2; Gene

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Objective To investigate the relationship between the polymorphisms of angiotensin Ⅱ receptor gene and the risk of primary aldosteronism (PA). Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine the 1166A/C polymorphism of AT1R gene and 1675A/G polymorphism of AT2R gene in 85 patients with PA and 100 healthy controls. Results There was no significant difference of AT1R 1166A/C genotypes (AA, AC, CC) and allele (A and C) frequency among patients and controls (χ2=0.430, P=0.806).There was obvious difference of AT2R 1675A/G genotypes (AA, AG, GG) and allele (A and G) frequency among two groups (χ2=6.121, P=0.013).The G allele was higher than A allele in PA group (χ2=6.767, P=0.009). Conclusion Homogenic mutation of 1675A/G site in AT2R gene may be one of risk factors of PA. Key words: Hyperaldosteronism; Receptor, angiotensin, type 2; Gene

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Available abstract

Objective To investigate the relationship between the polymorphisms of angiotensin Ⅱ receptor gene and the risk of primary aldosteronism (PA). Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine the 1166A/C polymorphism of AT1R gene and 1675A/G polymorphism of AT2R gene in 85 patients with PA and 100 healthy controls. Results There was no significant difference of AT1R 1166A/C genotypes (AA, AC, CC) and allele (A and C) frequency among patients and controls (χ2=0.430, P=0.806).There was obvious difference of AT2R 1675A/G genotypes (AA, AG, GG) and allele (A and G) frequency among two groups (χ2=6.121, P=0.013).The G allele was higher than A allele in PA group (χ2=6.767, P=0.009). Conclusion Homogenic mutation of 1675A/G site in AT2R gene may be one of risk factors of PA. Key words: Hyperaldosteronism; Receptor, angiotensin, type 2; Gene

Key concepts: Genotype, Allele, Restriction fragment length polymorphism, Medicine, Internal medicine, Gene polymorphism, Endocrinology, Allele frequency

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