Role of inflammatory response in correlation between Parkinson’s disease and cerebral small vessel disease

It is generally accepted that both Parkinson's disease (PD) and cerebral small vessel disease (CSVD) are chronic diseases of central nervous system which are very common in middle aged and elderly people. Although their clinical manifestations are different, a large number of studies have shown that there is similar pathogenesis in many respects, including age, genetic factors, environmental factors, oxidative stress and inflammatory reaction. Furthermore, inflammation is one of the important pathogenesis of PD and it aggravates the damage of dopamine neurons; inflammatory mechanisms are involved in the pathogenesis of CSVD, which may be involved in the pathogenesis of PD due to the immune responses that produce or accelerate the damage of dopaminergic neurons. This article will describe the relationship between PD and CSVD from the perspective of inflammation. Key words: Inflammation; Parkinson's disease; Cerebral small vessel disease; Pathogenesis