2015•International journal of pediatricsRequires access
Progress of a disintegrin and metalloproteinase 10 in urinary tract diseases
Ling Hou
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Abstract
A disintegrin and metalloproteinase 10 is a zinc dependent transmembrane type I multi-domain of protein which is highly conserved in evolution and mediates protein maturation and ectodomain shedding, with protein hydrolysis, cellular adhesion, cellular fusion and signal transmission. This article reviews its structure and function, the substrate and relative signaling pathways, the factors influencing its expression and catalytic activity, the research progress in urinary tract diseases.
Key words:
A disintegrin and metalloproteinase 10; Urinary tract